Ahh, I didn't knew that.

I've tried running this macro file in 1.23 now. In Plus, it got 'out of sync' while the player was on it's way to the 2nd AreaID. The macro kept playing alright, the player just went back and forth mindlessly in one area.

Then I tried it non-plussified. The player got a lot further, all the way into the Tzarin maze! However, at the beginning of the maze it took a wrong turn on the upper-left and that's where it goes cuckoo. It got stuck in a pattern spazzing out as if all buttons were pressed at once at a slight interval of a few seconds. Then at last I tried playing it windowed (non-plussified) to check if framerate somehow interferes, but it does exactly the same getting stuck at the Tzarin maze.

So in short:
The Macro gets out of sync in Plus. And gets stuck in a pattern in non-Plus.

Has anyone ever played this macro successfully from the beginning to the end? I doubt it.