Everyone seems to be forgetting proportionality here! If Jazz's Seekers did as much damage to a Reploid, or a hedgehog, or a petroleum-high soldier of fortune, as they did to another rabbit, they would take off 20-40% health in one hit.

Also, while in Sonic and MM/X you remain invincible for a few seconds after you get hit, in an FPS like Duke Nukem 3D, you keep being hit by a rapid fire weapon, with every bullet it fires. Therefore, if Jazz fired off a short stream of anything at Duke (3 if powered-up, 5 if not), our Devastator-toting hero(?) would get roasted pretty quick.

In Sonic, our blue-spined protagonist has to pick up rings to stay alive, correct? And with every hit he takes he loses all of the rings he has. If he has 150 rings, and he gets hit, he drops all of them. He'll only be able to pick up about 25 before they disappear. From this 25, he may be able to pick up 10 if he gets hit again. Simply avoid Sonic's spinning attacks, and keep up a hail of gunfire at him, and he'll eventually miss his last ring and fall to a well-placed shot. Not saying this won't take a heckuva long time.

As for Megaman X and Zero, to give them their informal names, that would probably be the most even matchup between the Jackrabbits and anyone else. Zero's sabre is a one-hit KO on generally any of Sigma's minions, excepting, of course, the Masters. However, it takes X and Zero a long time to charge up enough to use a sabre, and if they attempt to fire when they are hit, they have to charge up again. My recommendation: Keep firing, and don't stay in one spot for more than a tenth of a second. Besides, X and Zero move really slow if they're not dashing. Jazz's walk is about twice as fast as X's, and his run is about one-and-a-half to two times as fast as X's dash. Not only that, but Jazz can sustain his run for a lot longer than X can his dash. Jazz is also much more maneuverable than X, being able to uppercut five times his height, jump incredible distances, etc. X, on the other hand, only really has his dashing maneuvers: the standard ground dash; the air-dash; and the vertical air-dash. Of course, X has an advantage where he can slide down walls and such, so that puts him at a relative equal with the Jackrabbits in the maneuverability department. As was mentioned earlier, a battle between the Jackrabbits and the Hunters would be almost perfectly even to both sides.

If it were Sonic vs. the Hunters, Sonic would win in a flash. Since X and Zero die instantly from being hit with spikes, all Sonic would have to do is hit them both once. I mean, Sonic is made of spikes! He's a walking Reploid death trap!