Here is what I like:

Right hand = arrow keys = directions

Left hand = actions:

Center Enter: run
Right shift: jump
Right ctrl: shoot
Space: select weapons
T: talk

My side scrolling games have always been Rshift - jump, Rctrl - shoot, arrow keys for walking, and the nearby keys for other actions.

But I am thinking of making ] to select weapons, since its closer than space, but just out of the way enough so I won't push it by accident. I also would like to use my Playstation 2 controller for the game with the adapter I have. The game let me set the controls, but only as joypad 3 strangely enough. But anyway, it won't work in the game. Maybe it needs to be recognised as joypad 1 to work, but it doesn't let me bind keys there.

For PC games, I NEVER use defaults. They are never what I like. Sometimes I might only need to adjust controls by a bit, but I never ever use default controls in any PC games.