It's definitely original. o_o
That alone is already something that makes this an interesting piece. Never seen anything quite like it, I think.
The reason for the creepiness, I think, is mainly the fact that the lines of the face are so.. shaky. It looks blurred, trembling, you know. Smoother lines would easily make it seem less strange to the eye. Another thing might be the colors.. they are pretty pale, and they don't harmonize well... if you were going for an upbeat picture in the first place, vibrant colors would have been a better choice.