Yes it could, MVDK2 has a level Editor, A JJDS could have one as well IF it was 2d. This doesn't mean I'm for a JJDS idea.

I'm now going to tackle the points PurpleJazz brought up:
You're not wowing me with the "YOU CAN USE TWO SCREENS!" because we have no idea if a JJDS would be 2d or 3d. If it's 2d, then sure we could have two screens, but you're going to have a better resolution on the PC no matter what. If it's 3d, two screens for game play would be horrendusly dumb. Winner- PC

Tilesets drawn with a Stylus doesn't intrigue me at all. Just open up Paint, use the Paintbrush tool and try to make a decent Tileset. Heck, you can even use on of them touch-sensitive pad doohickeys I can't even remember the name of (just limit the size you can draw on it to the size of the DS touch screen) and use that instead of your mouse. Chances are, unless you're crazy good at drawing in small areas or with the mouse, even cheq will look better. Winner- PC

You can download much higher quality samples on the PC for music, and can also record much higher quality music samples. Heck, once the DS has those samples what is it supposed to do with them? A music editor, perhaps? Jeezus, do you want Jazz Jackrabbit Paint or Jazz Jackrabit DS? Remeber, the DS can only hold so much space, this isn't a PC we're working with. Winner- PC

I'm not tackling the online gaming, because I think PC can win with just one equation: World-wide Server Listing > Freind Codes