If there is, or someone could create, a tool that could enable a player to use a boss it would be really usefull. This way you won't have to rely on random boss paterns to play (assuming we will use bosses in this, 3 different character types seems to be a little on the short side). Maybe even some way to use Tweedle that way (something like a mastermind or something). Also if it's possible to make the things that the characters do when you dont move them usable at will, to prevent them from saying something (Jazz) or shooting a UFO (Spaz) while having a conversation. Finally something that can record it easily and that can be edited at any time is something that we really need (nooooo, duh?).

Aside from that I feel that that some sort of quest could work, with bases maybe put in somewhere, and to use different colours for the different characters.