About resolutions; perhaps if the whole thing was either in vectors, or made at seriously ridiculous sizes, then basically any resolution would work, and -- assuming you have an alpha channel in your graphics -- you get free anti-aliasing. Of course, vectors could add the bonus of being able to be manipulated in the game for some fun VFX(Such as making Jazz's ears spin around at the speed of light).
(Also, I agree with Treylina's above post)