It depends for me which keyboard layout I end up using. For driving games where you don't need to manually aim a weapon or for simpler platformers, numpad is my go-to for comfort, as can be seen in my video playlist. One of the newer platformers, Risk of Rain, I was fairly excited to find out my classic setup of 8 4 6 2 for directions, with center 5 as Jump, was perfectly compatible. Then I just used z,x,c,v for my abilities. Comparatively, I use WASD and space in Terraria, as I have to aim with the mouse. Not to mention quick access to the toolbox hotkeys.