I used to clear the original SP levels using solely the blaster, switching to other weapons only if destruct scenery required it. Then I started to play the (original) SP multiple times over the years using basically all weapons in different situations. And while the level design doesn't require it, it still felt rewarding killing everything with style!

In harder custom SP levels, I generally use what the designer intended to use (if any). Though blaster and buttstomping still works great in most of them..